Recombinant DNA, sequencing technologies, engineered cell systems, organoids and culturing systems, engineered microorganisms, antibodies (e.g., monoclonal, humanized, bispecific, multispecific), antibody engineering, antibody display technologies, biologics, nucleic acid and protein therapeutics (e.g., chimeric and fusion proteins), chimeric antigen receptors (CAR)-T cell technologies and therapy, gene therapy, vaccines (e.g., peptide and mRNA), siRNA, stem cell technologies, plant varieties, viruses, pharmaceutical formulations, disease biomarkers, and treatments and diagnostic methods for immune, proliferative, infectious, cardiac, neurodegenerative and metabolic diseases.